Myocardial infarction
History of definite or probable MI (EKG changes and/or enzyme changes)
CHF
Exertional or paroxysmal nocturnal dyspnea and has responded to digitalis, diuretics, or afterload reducing agents
Peripheral vascular disease
Intermittent claudication or past bypass for chronic arterial insufficiency, history of gangrene or acute arterial insufficiency, or untreated thoracic or abdominal aneurysm (≥6 cm)
CVA or TIA
History of a cerebrovascular accident with minor or no residua and transient ischemic attacks
Dementia
Chronic cognitive deficit
COPD
Connective tissue disease
Peptic ulcer disease
Any history of treatment for ulcer disease or history of ulcer bleeding
Liver disease
Severe = cirrhosis and portal hypertension with variceal bleeding history, moderate = cirrhosis and portal hypertension but no variceal bleeding history, mild = chronic hepatitis (or cirrhosis without portal hypertension)
Diabetes mellitus
Hemiplegia
Moderate to severe CKD
Severe = on dialysis, status post kidney transplant, uremia, moderate = creatinine >3 mg/dL (0.27 mmol/L)
Solid tumor
Leukemia
Lymphoma
AIDS