Myocardial infarction

History of definite or probable MI (EKG changes and/or enzyme changes)

CHF

Exertional or paroxysmal nocturnal dyspnea and has responded to digitalis, diuretics, or afterload reducing agents

Peripheral vascular disease

Intermittent claudication or past bypass for chronic arterial insufficiency, history of gangrene or acute arterial insufficiency, or untreated thoracic or abdominal aneurysm (≥6 cm)

CVA or TIA

History of a cerebrovascular accident with minor or no residua and transient ischemic attacks

Dementia

Chronic cognitive deficit

Peptic ulcer disease

Any history of treatment for ulcer disease or history of ulcer bleeding

Liver disease

Severe = cirrhosis and portal hypertension with variceal bleeding history, moderate = cirrhosis and portal hypertension but no variceal bleeding history, mild = chronic hepatitis (or cirrhosis without portal hypertension)

Moderate to severe CKD

Severe = on dialysis, status post kidney transplant, uremia, moderate = creatinine >3 mg/dL (0.27 mmol/L)